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However, both can cause gastrointestinal side effects that may be additive, and dehydration from these effects could affect methotrexate clearance

Casiraghi, M

And regulatory approvals already reflect this shift: Wegovy is approved to lower cardiovascular risk, Ozempic slows kidney disease progression, and semaglutide is cleared for metabolic dysfunctionassociated steatohepatitis (MASH) with fibrosis